Is Glutathione All That It’s Made Out To Be?

Glutathione, one of the most popular ingredients popping up on our Instagram feeds these days, has received considerable attention in the last year. It might not be as trendy as some popular skincare staples (looking at you, retinol), but it boasts an impressive résumé in skin health. It fights free radicals, enhances radiance, and helps prevent fine lines. There's a lot to learn about this powerful ingredient, so we’ve done a deep dive and sought expert advice to help you figure out whether it's a myth or a miracle.

What is glutathione?

Glutathione, a powerful antioxidant found in every cell of the body, is composed of three amino acids: glutamic acid, glycine, and cysteine. Unlike most antioxidants, the body can produce glutathione in the liver, making it unique and essential for various bodily functions like neutralizing harmful free radicals, supporting the immune system, and aiding the detoxification process. While glutathione naturally occurs in the body and helps defend skin against the visible effects of environmental damage, its levels unfortunately decline as we age.

Though topical skincare is one route to consider, glutathione can also be incorporated through supplements or as part of a healthy diet to improve the overall health of your skin. “It’s also available in foods such as watermelon, leafy vegetables, asparagus, and avocado,” says Dr. Madhuri Agarwal of Yavana Aesthetics Clinic, “It was originally given as a drug to chemotherapy patients to circumvent the toxic effects of chemo. It is also approved for use in liver disorders like liver cirrhosis.”

What does glutathione do to your skin?

Glutathione is a great addition to your skincare routine, especially for those suffering from hyperpigmentation and discolouration, as the three amino acids mentioned above help restore the skin’s surface and brighten the complexion. “It’s a well-documented immunity booster,” says Dr. Madhuri, “Glutathione improves overall immunity and aids in healthy skin. Skin brightening is also seen with glutathione on oral intake. It slows down melanin production and thereby helps in reducing pigmentation.” As an antioxidant, it reduces photodamage and early signs of ageing. However, there are no studies or data that show the efficacy of glutathione in treating acne and fine lines, she adds.

How should you use glutathione?

It should go without saying that glutathione should not be taken without the advice of a dermatologist, especially orally. It has good results when taken orally regularly, but topical application has limited efficacy in most conditions. “The effects of glutathione will vary in different individuals; hence, it should never be self-administered without a prescription,” says Dr. Madhuri.

Who should use glutathione?

It is great for those who want to work on improving their overall skin texture, tone, and complexion, and reverse signs of damage and pigmentation.

What are some of the side effects of glutathione?

When taken by mouth, glutathione is possibly safe when used in doses of up to 500 mg daily for up to two months. “Common side effects in the form of stomach upset and allergic reactions might occur in rare cases,” says Dr. Madhuri. It’s usually a safe ingredient when taken under medical supervision in the right quantity and takes time to show results.

To sum it up, glutathione is an important antioxidant produced in the body with multiple benefits that can most definitely help with various ailments. The quality and dosage of this ingredient determine the benefits you can derive from it. Injectables and orally consuming this antioxidant under the guidance of a trained professional will make sure you achieve the best results possible.