Does Nature’s Ozempic Really Work?

As pop culture again stands at the skinny body altar, and with ozempic becoming the trend du jour, we are here wondering whether the latest gimmick called ‘berberine’ or ‘nature’s ozempic’ give you a snatched waist. 

But, before we dive into the conversation may we remind you that before Ozempic became a weight-loss drug, it was a drug prescribed for diabetes. Similarly, berberine has been around for centuries as a remedy for bloating, poor metabolism, and regulating blood sugar. 

We have many questions about berberine: is it safe? Worth it? Will I lose weight instantly? Or is it just another diet culture trap? We decode it ahead. 

What is berberine?

Berberine is a natural compound found in certain plants, particularly those belonging to the Berberis genus. This genus includes around 400-500 different plant species. Shaloo Shrey Aeren, Co-founder, Bio Resurge Wellness says “Berberine is most concentrated in the roots of these plants, typically ranging from 1.6 to 5.0% of the plant's dry weight. European Barberry is known to have one of the highest concentrations of berberine, reaching approximately 5%.” 

However, berberine’s roots go back to Ayurveda too. Dr Swathi Ramamurthy, Head of R&D Herbal Chakra says it has been used for centuries for various health problems. 

“In Ayurveda, Daruharidra (Berberis aristata), also known as Indian Barberry, is a revered herb with multifaceted therapeutic applications. It looks like a yellow-coloured wood resembling turmeric. It is widely utilised for its detoxifying, anti-inflammatory, and antimicrobial properties.”

Many often confuse berberine with turmeric. However, the latter primarily helps with acute and sub-acute inflammatory responses related to immunity, whereas berberine works better in chronic inflammation. 

For its versatile therapeutic properties, Daruharidra is mentioned in classical Ayurvedic texts like Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya. “It acts as a digestive stimulant and supports the liver, effectively managing conditions like jaundice, loss of appetite, and dysentery. It also helps in managing blood sugar levels and preventing complications of diabetes,” shares Ramamurthy.

Does Berberine really make a difference?

With costs for Ozempic going up to a $1,000 ( 86,535 INR), many are turning to this inexpensive OTC supplement. Berberine may offer several health benefits. Studies suggest it can help lower blood sugar levels, which is important for people with diabetes. “It may also aid in weight management. Additionally, berberine may support heart health and gut health. Generally, berberine is considered safe for most adults when taken as directed,” advises Shaloo Shrey Aeren. However, it is crucial to avoid berberine supplements if you are pregnant. 

It takes time to witness visible changes in the body after starting berberine supplementation. “Some individuals may experience noticeable effects within a few weeks, while others may take longer. Generally, it is suggested to take berberine consistently at a dosage of 1.5 grams per day for at least 12 weeks to observe potential benefits,” Shaloo adds. 

However, if not consulted with a doctor it can cause gastric irritation, constipation, colicky pain, and other gastrointestinal disturbances. 

How many kilos can you lose with berberine?

Berberine is known to reduce chronic inflammation and accelerate metabolism, thus helping in weight loss. With Reels coming one after another on your feed to lower inflammation and cortisol levels, the role of Berberine has increased more than ever. “Thanks to celebrities like Vidya Balan openly talking about it. This is one of the best herbal anti-inflammatory supplements for weight loss. One can expect a weight loss of around 1-1.5kg per week. It also helps in reducing insulin resistance at a cellular level, which improves glucose metabolism, thus aiding in diabetes management, shares Ramamurthy.”

Is Berberine really meant for me? 

It is generally recommended to avoid consuming alcohol while taking berberine. Alcohol may interact with berberine and potentially increase the risk of side effects. Smoking may also interfere with berberine. “Additionally, it is important to be cautious about combining berberine with certain medications, such as antibiotics, anti-inflammatory drugs, and anaesthetics. It is always advisable to consult with a healthcare professional before starting any new supplement, especially if you are taking any medications” adds Shaloo.